The association between serum levels of oxLDL-lgG and oxLDL-lgM autoantibody with adult acute myeloblastic leukaemia Lipids in Health and Disease 2010, 9:11 doi:10.1186/1476-511X-9-11

Aim: To evaluate the relationship between serum antibodies against ox-LDL levels and adult acute myeloblastic leukemia (AML). Methods: Forty three patients with AML and 52 normal controls were enrolled in this study in the Department of Hematology, Tumor Center of Qilu Hospital of Shandong University from Feb. 2008 to Mar.2009. Serum lgG and lgM antibodies versus the oxLDL levels were evaluated by ELISA method. Data was analyzed by covariance and binary Logistic regression. Results: Serum mean levels of oxLDL –lgG in patients (38.92±21.1259ug/ml) were significantly lower than in control subjects (78.88±9.3705ug/ml); Meanwhile, Serum mean levels of oxLDL –lgM in patients (20.53±10.2990IU/L) were significantly higher than in control subjects (10.29±10.5771IU/L). Binary logistic regression showed the odds ratios of association of oxLDL-lgG and oxLDL-lgM with adult AML were 0.72(95%CI: 0.55-0.94) and 1.11(95%CI: 1.01-1.21) respectively after adjusted for potential confounders. Conclusion: In the preliminary investigation we found a descensive oxLDLlgG and